Thanks for all the help and advice. I'm definately going to do my homework and plan it right. (Im a mechanical engineer by trade, so my wife claims I tend spend too much time researching and I occasionally over analyze things. )
The spot that Im planning is in my hobby room. Right now it is setup as my gun & re-loading room, but Im going to move most of that to the shop. I want to put it in the corner, so I can view one side from the adjacent bedroom and the front would be visable from our family room. Im going to measure the space to see what looks right, but Im not sure if 10' length will work. It will probably have to be 8'-9' to be centered on the wall. That would give me one full side and the back with plenty of access.
I have an alternate spot in mind, but it would involve moving our small built in wet bar. The plus to that is I would have easy access to the water and drain lines, but I wouldnt have as much space around the back of the tank, so I couldnt go as large. It would also be in direct line with the pool table, so I would have to put up some sliding doors to protect from flying balls. I can just imagine a wild shot shattering glass and dumping 300+ gallons of salt water into the basement.