If you need to clean equipment do so at least a week before you’re going in vacation. Like the post above, things need to be stable. Don’t clean your skimmer the night before you have to leave. Don’t touch the return pump the day you’re leaving. Etc. What I do the day before vacation is simply check to make sure dosing lines aren’t clogged and I refill the dosing containers and the rest is in the apps I’m using. (There is an app for everything). I also have a spare return pump on standby just in case. A couple people you trust is a must in case things don’t show right on your apex and camera.
At the end of the day if you don’t tweak anything for weeks in a row while you’re home you shouldn’t have issues.